The Association of Seminal Plasma Antioxidant Levels and Sperm Chromatin Status with Genetic Variants ofGSTM1andGSTP1(Ile105Val and Ala114Val) in Infertile Men with Oligoasthenoteratozoospermia
نویسندگان
چکیده
منابع مشابه
The Association of Seminal Plasma Antioxidant Levels and Sperm Chromatin Status with Genetic Variants of GSTM1 and GSTP1 (Ile105Val and Ala114Val) in Infertile Men with Oligoasthenoteratozoospermia
In this study we aimed to examine the effects of genetic variants of GSTM1 and GSTP1 (Ile105Val and Ala114Val) on GST activity, seminal oxidative stress and sperm chromatin status in infertile men with oligoasthenoteratozoospermia (OAT). The study population (n=121) consisted of 95 infertile men with OAT and 26 controls with normozoospermia. Multiplex polymerase chain reaction (PCR) and polymer...
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conclusions our findings indicated that oxidative stress could play an essential role in male infertility caused by varicocele and may impair spermatogenesis leading to infertility. objectives in the current study, we aimed to assess the tac (total antioxidant capacity) and mda (malondialdehyde) as stress oxidative markers in infertile men with varicocele and fertile men, and moreover, their co...
متن کاملthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Antioxidant levels in blood and seminal plasma and their impact on sperm parameters in infertile men.
Excess reactive oxygen species (ROS) beyond the scavenging capacity of antioxidants leads to DNA damage and oxidation of lipoprotein components at the cellular and subcellular level. The oxidative stress (OS) adversely affects sperm function by altering membrane fluidity, permeability and impairs sperm functional competence. In the present study, the OS status in seminal plasma and blood serum ...
متن کاملP-19: Association of Poor Chromatin Remodeling with Cytosolic ROS and Mitochondrial ROS in Sperm of Infertile Men
Background: Cytoplasm and mitochondria are considered as the major origins of sperm ROS production. Sperm is prone to DNA damage by exposure to ROS or due impaired chromatin remodeling or low DNA protamination. Therefore, the aim of this study was to see if there is any association between impaired chromatin packaging and origin of ROS production. Materials and Methods: Cytosolic ROS, mitochond...
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ژورنال
عنوان ژورنال: Disease Markers
سال: 2013
ISSN: 0278-0240,1875-8630
DOI: 10.1155/2013/635091